The lore of 2545 involves a dystopian future where androids turn on humans, resulting in the genocide of the human race. Some humans were able to escape Earth in a spaceship, and that group begins a search for a new interstellar home. The project features three factions:
- Terrarian: Androids that are friendly with humans. Their mission is the full restoration of humanity.
- Oblirian: Androids that are the enemies of humanity. Their mission is the complete genocide of humanity.
- Aetherian: Indifferent to humanity, they seek the restoration of world peace, with or without humans.
Key roadmap items include an art gallery and novel.